In 1996 it was estimated that about 10 million people in the United States took chromium supplements at a cost of $ 150 million dollars per year, largely as a result of claims of beneficial effects on insulin action and glucose tolerance. The study was registered on the NIH registry () and the identifier is NCT00846248Ĭhromium is a very commonly used nutritional supplement. Caution therefore should be exercised in recommending the use of this supplement. Further, subjects who have high serum chromium levels paradoxically had a decline in insulin sensitivity. ConclusionsĬhromium therapy did not improve insulin sensitivity in non-obese normoglycemic individuals. This effect could not be explained by changes in physiological parameters such as body weight, truncal fat and serum lipids with chromium therapy. There was, however, a strong association between serum chromium and change in insulin resistance (β = -0.83, p=0.01), where subjects with the highest serum chromium had a worsening of insulin sensitivity. ResultsĪfter 16 weeks of chromium picolinate therapy there was no significant change in insulin sensitivity between groups (p=0.83). Pre-specified secondary endpoints included fasting lipids, blood pressure, weight, body composition measured by DXA scan. The primary endpoint was change in insulin sensitivity as measured by euglycemic hyperinsulinemic clamp. After baseline studies, the subjects were randomized to placebo or chromium picolinate 500 μg twice a day. MethodsĪ double blind placebo-controlled randomized trial was conducted on 31 non-obese, normoglycemic subjects. In the present studies, we test the hypothesis that chromium supplementation raises serum chromium levels and correspondingly improves insulin sensitivity. doi:10.The use of chromium supplements is widespread for the prevention and treatment of diabetes mellitus but there are conflicting reports on efficacy, possibly reflecting discrepant effects across different populations. Chromium supplementation in human health, metabolic syndrome, and diabetes. The Nutritional Biochemistry of Chromium (III). Chromium supplements in health and disease. A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity. Tsang C, Taghizadeh M, Aghabagheri E, Asemi Z, Jafarnejad S. Effects of chromium picolinate on food intake and satiety. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: Effect on carbohydrate craving. doi:10.1253/circj.CJ-17-0032ĭocherty JP, Sack DA, Roffman M, Finch M, Komorowski JR. Chromium exposure and risk of cardiovascular disease in high cardiovascular risk subjects - nested case-control study in the Prevention With Mediterranean Diet (PREDIMED) Study. Gutiérrez-Bedmar M, Martínez-González MÁ, Muñoz-Bravo C, et al. Effect of chromium supplementation on glucose metabolism and lipids: A systematic review of randomized controlled trials. Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions. Pattar GR, Tackett L, Liu P, Elmendorf JS. Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes. Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Comparison of chromium and iron distribution in serum and urine among healthy people and prediabetes and diabetes patients.
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